Down and almost out in Scotland: George Orwell, tuberculosis and getting streptomycin in 1948.

Tubercles of the choroid.

In 1948 two of us (Illingworth and Wright) reviewed the literature conceming tubercles of the choroid and described the natural history of the disease as seen in children under our care. We pointed out that the favourable response of children with miliary or meningeal tuberculosis to streptomycin treatment had for the first time made possible the study of the natural history of choroidal tuberc...

Treatment of tuberculous meningitis with streptomycin.

Present status of streptomycin in tuberculosis.

Streptomycin has become estabiished as a valuable weapon in the therapy of tuberculous infections. Tuberculosis is a protein disease, its symptomatologg and prognosis variable. As is well known, spontaneous healing may occur without benefit of presently accepted therapeutic measures. Hence it is readily apparent that the final evaluation of any tubercu!o-chemotherapeutic agent will be possible ...

Sensitivity of the tubercle bacillus to streptomycin before and during specific therapy.

Shortly after the demonstration of a therapeutic effect of streptomycin upon tuberculous infections in animals (1, 2) and in the human (3), Youmans and his co-workers (4) found that cultures from patients subsequent to such specific therapy yielded organisms which were resistant to streptomycin. These investigators not only observed that 7 of 8 strains recovered from 12 patients before and afte...

Streptomycin in tuberculous meningitis; report of a case.

under critical observation at the present time. The advent of this new drug was greeted with much enthusiasm but further clinical experience on a greater number and variety of cases has led to better appreciation of its merits and dangers. It is true that in most cases of tuberculous meningitis the immediate effects of streptomycin therapy have been so striking as to promise hope of recovery. O...